Year 2267. The ecosystem of Earth has been destroyed and mankind is forced to live in orbit. The story of CARGO takes place on the derelict spaceship KASSANDRA on its 8 year journey to a remote freight-station in deep space.
The young and inexperienced medical officer LAURA PORTMANN (Anna Katharina Schwabroh) is the only person awake on board. The rest of the crew lies frozen in cryosleep. During her daily patrols, through the eerily empty ship, she begins to get the feeling that she may not be alone on board. She wakes up part of the crew. A dangerous reconnaissance mission into the vast and ice-cold cargo hold ends in a catastrophe, where the captain of the ship dies. The remainder of the crew is awakened. During a second discovery mission into the cargo hold, the crew finds out that the ship carries something completely different than officially declared. Laura uncovers a large-scale conspiracy, where the government is withholding groundbreaking information about the current state of evolution back home on Earth. After a dramatic showdown, Laura is able to shut down the source of misinformation and bring back proof to uncover the conspiracy. However, this inconvenient truth may start a revolution.